| 3-正丙基-5-羧基-1-甲基吡唑的合成研究 |
| |
| 引用本文： | 沈之芹.3-正丙基-5-羧基-1-甲基吡唑的合成研究[J].化学世界,2002,43(4):208-210. |
| |
| 作者姓名： | 沈之芹 |
| |
| 作者单位： | 上海石油化工研究院催化四部,上海,201208 |
| |
| 摘 要： | 以 2 -戊酮和草酸二乙酯为起始原料 ,经 Claisen缩合、环化、甲基化和皂化等反应制得目标化合物 3-正丙基 - 5 -羧基 - 1 -甲基吡唑 3。文献报道的合成方法为四步法 ,在此基础上加以改进 ,形成了两种新的合成路线 ,即三步法和两步法 ,其收率均高于四步法 ,高出 2 7.0 %
|
| 关 键 词： | 3-正丙基-5-羧基-1-甲基吡唑 两步法 三步法 四步法 |
| 文章编号： | 0367-6358(2002)04-0208-03 |
| 修稿时间： | 2001年8月15日 |
Synthesis of 1-Methyl-3-n-propylpyrazole-5-carboxylic Acid |
| |
| SHEN Zhi,qin.Synthesis of 1-Methyl-3-n-propylpyrazole-5-carboxylic Acid[J].Chemical World,2002,43(4):208-210. |
| |
| Authors: | SHEN Zhi qin |
| |
| Abstract: | Methyl 3 n propylpyrazole 5 carboxylic acid 3 was prepared from 2 pentanone and diethyloxalate as starting materials. The synthetic route reported in literature consists of four steps, i.e. Claisen condensation, cyclization, methylation and hydrolysis. Two new routes with two steps and three steps are interduced. The yields of the three step and two step methods are 27.0% more than that of the four step method. |
| |
| Keywords: | methyl 3 n propylpyrazole 5 carboxylic acid two step method three step method four step method |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
