氟胺氰菊酯的合成

[目的]开发氟胺氰菊酯的工业化合成线路,打破了国外的技术垄断。[方法]以D-缬氨酸为起始原料合成中间体(R)-氟胺氰菊酸,在甲磺酰氯、吡啶、4-二甲氨基吡啶和甲磺酸等为催化剂下与间苯氧基苯甲醛反应合成氟胺氰菊酯。[结果]氟胺氰菊酯纯度达95%以上,纯度达到了日本进口的原药水平,目前已经处于公斤级生产阶段。[结论]该合成路线具有成本低、操作安全、产品纯度高等优点。

Synthesis of Fluvalinate

a synthetic route of fluvalinate was developed and industrialized breaking the monopoly of foreign technology.[Methods] Fluvalinate was synthesized by reaction of(R)-fluvalinate acid prepared from D-Val with 3-phenoxybenzaldehyde at the presence of catalysts such as methanesulfonyl chloride,pyridine,DMAP and mesylate.[Results] The purity of fluvalinate is more than 95%,which reaches the level of fluvalinate imported from Japan.At present,this synthetic route is in the stage of scale-up kilogram synthesis.[C...