| 5-甲氧甲基-2,3-吡啶二羧酸的合成 |
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| 引用本文： | 杜梦,廖道华,刘少春,刘炳祥,张曙光,陈倩. 5-甲氧甲基-2,3-吡啶二羧酸的合成[J]. 农药, 2011, 50(6) |
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| 作者姓名： | 杜梦 廖道华 刘少春 刘炳祥 张曙光 陈倩 |
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| 作者单位： | 华东理工大学药学院,上海,200237 |
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| 摘 要： | [目的]5-甲氧甲基-2,3-吡啶二羧酸是合成除草剂甲氧咪草烟的关键中间体,具有重要的研究和生产价值。[方法]以马来酸二乙酯为起始原料,经过羟胺取代、脱水、加成环合和水解制成5-甲氧甲基-2,3-吡啶二羧酸。[结果]反应总收率42.4%,含量95.6%。[结论]该路线可以作为工业生产路线。
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| 关 键 词： | 除草剂 甲氧咪草烟 5-甲氧甲基-2 3-吡啶二羧酸 合成 |
Synthesis of 5-(methoxymethyl)pyridine-2,3-dicarboxylic acid |
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| DU Meng,LIAO Dao-hua,LIU Shao-chun,LIU Bing-xiang,ZHANG Shu-guang,CHEN Qian. Synthesis of 5-(methoxymethyl)pyridine-2,3-dicarboxylic acid[J]. Pesticides, 2011, 50(6) |
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| Authors: | DU Meng LIAO Dao-hua LIU Shao-chun LIU Bing-xiang ZHANG Shu-guang CHEN Qian |
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| Affiliation: | DU Meng,LIAO Dao-hua,LIU Shao-chun,LIU Bing-xiang,ZHANG Shu-guang,CHEN Qian(Pharmacy School,East China University of Science and Technology,Shanghai 200237,China) |
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| Abstract: | 5-(methoxymethyl)pyridine-2,3-dicarboxylic acid,the main intermediate of imazamox had great value in reasearch and industrial production.[Methods] 5-(methoxymethyl)pyridine-2,3-dicarboxylic acid was synthesized from diethyl maleate via substitution reaction,dehydration,condesation and hydrolysis.[Results] The total yield was 42.4%,and the purity was 95.6%.[Conclusions] This synthetic route can be used in industry. |
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| Keywords: | herbicide imazamox 5-(methoxymethyl)pyridine-2 3-dicarboxylic acid synthesis |
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