Exploiting multilevel parallelism on a many-core system for the application of hyperheuristics to a molecular docking problem |
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Authors: | José M. Cecilia José-Matías Cutillas-Lozano Domingo Giménez Baldomero Imbernón |
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Affiliation: | 1.Polytechnic School,Catholic University of San Antonio of Murcia (UCAM),Murcia,Spain;2.Department of Computing and Systems,University of Murcia,Murcia,Spain |
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Abstract: | The solution of Protein–Ligand Docking Problems can be approached through metaheuristics, and satisfactory metaheuristics can be obtained with hyperheuristics searching in the space of metaheuristics implemented inside a parameterized schema. These hyperheuristics apply several metaheuristics, resulting in high computational costs. To reduce execution times, a shared-memory schema of hyperheuristics is used with four levels of parallelism, two for the hyperheuristic and two for the metaheuristics. The parallel schema is executed in a many-core system in “native mode,” and the four-level parallelism allows us to take full advantage of the massive parallelism offered by this architecture and obtain satisfactory fitness and an important reduction in the execution time. |
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