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| 3-奎宁环酮盐酸盐的合成工艺改进 | |
| 引用本文： | 陈年根,杨昌云,刘新泳,任兆平. 3-奎宁环酮盐酸盐的合成工艺改进[J]. 化学试剂, 2008, 30(2): 145-146 |
| 作者姓名： | 陈年根 杨昌云 刘新泳 任兆平 |
| 作者单位： | 1. 海南医学院,药学系,海南,海口,571101 2. 解放军180医院,药剂科,福建,泉州,362000 3. 山东大学,药学院,山东,济南,250012 |
| 摘 要： | 改进了标题化合物的合成工艺.以4-吡啶甲酸乙酯和溴乙酸乙酯为起始原料,经亲核加成、还原、解盐、Dieckmann缩合、成盐制得标题化合物,总收率为54.5%,其结构经IR、13CNMR和1HNMR确证.改进后的工艺操作相对简单,易于工业化生产. |
| 关 键 词： | 3-奎宁酮盐酸盐 合成工艺 改进 |
| 文章编号： | 0258-3283（2008）02-0145-02 |
| 收稿时间： | 2007-09-24 |
| 修稿时间： | 2007-09-24 |
Improved method for synthesis of 3-quinucfidone hydrochloride |
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| CHEN Nian-gen,YANG Chang-yun,LIU Xin-yong,REN Zhao-ping. Improved method for synthesis of 3-quinucfidone hydrochloride[J]. Chemical Reagents, 2008, 30(2): 145-146 | |
| Authors: | CHEN Nian-gen YANG Chang-yun LIU Xin-yong REN Zhao-ping |
| Abstract: | This article refers to the improved method for the preparation of 3-quinuclidone hydrochloride. 3-Quinuclidone hydrochloride was synthesized from ethyl isonicotinate and ethyl bromoacetate as starting materials via the nucleophilic addition, followed by reduction, neutralization, the Dieckmann condensation, and salification. The structure of the target compound was confirmed by IR, ^1HNMR and ^13CNMR, and the overall yield reached 54.5 % . The process was simplified by modifying the reaction conditions and was suitable for manufacturing in commercial scale. |
| Keywords: | 3-quinuclidone hydrochloride synthetic process improvement |
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