Low temperature fabrication of high strength porous calcium phosphate and the evaluation of the osteoconductivity |
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Authors: | Xianzhu Yu Shu Cai Guohua Xu Wei Zhou Dongmei Wang |
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Affiliation: | (1) Key Laboratory for Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin University, Tianjin, 300072, People’s Republic of China;(2) China Nation Academy of Nano Technology and Engineering, Tianjin, 300457, People’s Republic of China;(3) Shanghai Changzheng Hospital, Shanghai, 200003, People’s Republic of China; |
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Abstract: | Porous NaO2–MgO–CaO–P2O5 bioglass doped beta-tri-calcium phosphate (β-TCP) bioceramic possessing high mechanical properties and well pore structure
with high porosity and high pore connectivity has been prepared through dipping method with the porous polyurethane as the
pore forming template. The sintering mechanism and the mechanical properties of the bioglass doped β-TCP scaffold have been
investigated by the X-ray diffraction (XRD) analysis, Scanning electron microscope (SEM) and thermal differential analysis
(DTA). The scaffold’s in vivo osteoconductivity has been evaluated by implantation of scaffolds into the femurs of New Zealand
rabbits. The results show that the porous structure can achieve the densification process at a low temperature about 950°C
by a solid solution sintering mechanism and hence dense macropore scaffold with a compressive strength of 4.32 MPa when the
porosity is 75% has been obtained. The in vivo test shows that the Na2O–MgO–CaO–P2O5 bioglass doped porous β-TCP bioceramic has a relatively fast bone formation after implantation; after 1 month implantation
new deposited bone tissue has been detected on the strut of the porous scaffold and degraded particles also has been found
on the surface of the new formed bone. After 6 months implantation the porous scaffold has been thoroughly covered with new
formed bone. Results show that the Na2O–MgO–CaO–P2O5 bioglass doped porous β-TCP bioceramic is potential bone tissue engineering scaffold for orthopedic use. |
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