首页 | 本学科首页   官方微博 | 高级检索  
     


Mechanisms Underlying the Anti-Aging and Anti-Tumor Effects of Lithocholic Bile Acid
Authors:Anthony Arlia-Ciommo  Amanda Piano  Veronika Svistkova  Sadaf Mohtashami  Vladimir I. Titorenko
Affiliation:Department of Biology, Concordia University, 7141 Sherbrooke Street, West, SP Building, Room 501-13, Montreal, QC H4B 1R6, Canada; E-Mails: (A.A.-C.); (A.P.); (V.S.); (S.M.)
Abstract:Bile acids are cholesterol-derived bioactive lipids that play essential roles in the maintenance of a heathy lifespan. These amphipathic molecules with detergent-like properties display numerous beneficial effects on various longevity- and healthspan-promoting processes in evolutionarily distant organisms. Recent studies revealed that lithocholic bile acid not only causes a considerable lifespan extension in yeast, but also exhibits a substantial cytotoxic effect in cultured cancer cells derived from different tissues and organisms. The molecular and cellular mechanisms underlying the robust anti-aging and anti-tumor effects of lithocholic acid have emerged. This review summarizes the current knowledge of these mechanisms, outlines the most important unanswered questions and suggests directions for future research.
Keywords:bioactive lipids   lipid metabolism   lipidomics   bile acids   aging and age-related diseases   cancer   anti-aging and anti-tumor therapeutic agents   endoplasmic reticulum   mitochondria   cell death
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号