Mechanisms Underlying the Anti-Aging and Anti-Tumor Effects of Lithocholic Bile Acid |
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Authors: | Anthony Arlia-Ciommo Amanda Piano Veronika Svistkova Sadaf Mohtashami Vladimir I. Titorenko |
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Affiliation: | Department of Biology, Concordia University, 7141 Sherbrooke Street, West, SP Building, Room 501-13, Montreal, QC H4B 1R6, Canada; E-Mails: (A.A.-C.); (A.P.); (V.S.); (S.M.) |
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Abstract: | Bile acids are cholesterol-derived bioactive lipids that play essential roles in the maintenance of a heathy lifespan. These amphipathic molecules with detergent-like properties display numerous beneficial effects on various longevity- and healthspan-promoting processes in evolutionarily distant organisms. Recent studies revealed that lithocholic bile acid not only causes a considerable lifespan extension in yeast, but also exhibits a substantial cytotoxic effect in cultured cancer cells derived from different tissues and organisms. The molecular and cellular mechanisms underlying the robust anti-aging and anti-tumor effects of lithocholic acid have emerged. This review summarizes the current knowledge of these mechanisms, outlines the most important unanswered questions and suggests directions for future research. |
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Keywords: | bioactive lipids lipid metabolism lipidomics bile acids aging and age-related diseases cancer anti-aging and anti-tumor therapeutic agents endoplasmic reticulum mitochondria cell death |
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