| 磷钨钼酸催化合成4-苯基-6-甲基-5-乙氧羰基-3，4-二氢嘧啶-2（H）-酮 |
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| 引用本文： | 杨水金,童文龙. 磷钨钼酸催化合成4-苯基-6-甲基-5-乙氧羰基-3，4-二氢嘧啶-2（H）-酮[J]. 化工中间体, 2007, 0(1): 22-24 |
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| 作者姓名： | 杨水金 童文龙 |
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| 作者单位： | 湖北师范学院,化学与环境工程系,湖北,黄石,435002 |
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| 摘 要： | 以磷钨钼杂多酸为催化剂，无水乙醇为溶剂，苯甲醛、乙酰乙酸乙酯、尿素为原料，合成了4-苯基-6-甲基-5-乙氧羰基-3，4-二氢嘧啶-2（H）-酮，系统研究了催化剂用量、反应温度、反应时间、原料配比诸因素对产品收率的影响。实验表明：磷钨钼杂多酸是合成4-苯基-6-甲基-5-乙氧羰基-3，4-二氢嘧啶-2（H）-酮的良好催化剂。确定的最优合成工艺条件为：尿素37．5mmol时，n（苯甲醛）：n（乙酰乙酸乙酯）：n（尿素）=1：1．2：1．5，催化剂用量为反应物料总质量的1．5%，反应温度为60℃，反应时间1．0h。在此条件下，产品收率可达44．6%.
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| 关 键 词： | 3,4-二氢嘧啶-2(H)-酮 磷钨钼酸 Biginelli反应 催化 |
| 文章编号： | 1006-253x（2007）01-022-3 |
| 收稿时间： | 2006-10-08 |
| 修稿时间： | 2006-10-08 |
Synthesis of 4-Phenyl-6-Methyl-5-Ethoxycarbonyl-3,4-Dihydropyrimidin-2(H)-One Catalyzed with H3PW6Mo6O40 |
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| YANG Shui-jin,TONG Wen-long. Synthesis of 4-Phenyl-6-Methyl-5-Ethoxycarbonyl-3,4-Dihydropyrimidin-2(H)-One Catalyzed with H3PW6Mo6O40[J]. , 2007, 0(1): 22-24 |
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| Authors: | YANG Shui-jin TONG Wen-long |
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| Affiliation: | YANG Shui-jin, TONG Wen-long (Department of Chemistry and Environmental Engineering, Hubei Normal University, Huangshi 435002,Hubei, China) |
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| Abstract: | 4-Phenyl-6-methyl-5-ethoxycarbonyl-3,4-dihydropyrimidin-2（H）-one was synthesized from benzaldehyde, ethyl acetoacetate, and urea with H3PW6Mo6O40 as catalyst and anhydrous ethanol as solvent. The effects of reaction conditions on the yield of the product were investigated and the optimum conditions were determined as follows：n（benzaldehyde）：n（ethyl acetoacetate）：n（urea 37.5 mmol）= 1.0：1.2：1.5, the quantity of catalyst was 1.5% quantity of the feed stock, reaction temperature 60℃, and reaction time 1.0 h. The yield of the product was up to 44.6%. |
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| Keywords: | 3 4-dihydropyrimidin-2(H)-one H3PW6Mo6O40 Biginelli reaction catalysis |
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