| α-甲基-缩二乙醇酸二乙酯的合成 |
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| 引用本文： | 刘国兵. α-甲基-缩二乙醇酸二乙酯的合成[J]. 山东化工, 2010, 39(1): 5-7 |
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| 作者姓名： | 刘国兵 |
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| 作者单位： | 青岛科技大学,化工学院,山东,青岛,266042 |
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| 摘 要： | 采用重氮乙酸乙酯(EDA)与乳酸乙酯在无水硫酸铜催化下进行O-H插入反应合成α-甲基-缩二乙醇酸二乙酯。讨论了反应时间,催化剂用量,反应温度和物料比例对插入反应收率的影响,在优化反应条件下产率为58.8%。产品纯度大于98%。
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| 关 键 词： | α-甲基-缩二乙醇酸二乙酯 卡宾 O—H插入反应 无水硫酸铜 |
Synthesis of Ethyl 2-(2-Ethoxy-2-oxoethoxy)-propionate |
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| LIU Guo-bing. Synthesis of Ethyl 2-(2-Ethoxy-2-oxoethoxy)-propionate[J]. Shandong Chemical Industry, 2010, 39(1): 5-7 |
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| Authors: | LIU Guo-bing |
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| Affiliation: | LIU Guo -bing( College of Chemical Engineering , Qingdao University of Science and Technology, Qingdao 266042, China) |
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| Abstract: | Ethyl diazoacetate （EDA） undergoes a facile anhydrous cupric sulfate carbenoid mediated O -H insertion reaction with ethyl lactate to afford the title compound . The effects of reaction time , catalyst ,reaction temperature as well as the ratio of ethyl lactate and EDA on the insertion yield were discussed. Under optimized reaction conditions the title compound was obtained to be a 58.8% yield. The purity of product was over 98%. |
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| Keywords: | ethyl 2 - （ 2 - ethoxy -- 2 - oxoethoxy ） - propionate carbene O - H insertion reaction anhydrous cupric sulfate |
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