Sonochemical synthesis of 3-methyl-4-arylmethylene isoxazole-5(4H)-ones by amine-modified montmorillonite nanoclay |
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| Affiliation: | 1. Malaysia-Japan International Institute of Technology, International Campus, Universiti Teknologi Malaysia, 54100 Kuala Lumpur, Malaysia;2. Advanced Materials Research Group, Institute of Hydrogen Economy, Universiti Teknologi Malaysia, International Campus, Jalan Semarak, 54100 Kuala Lumpur, Malaysia;1. Gas Conversion Department, Faculty of Petrochemicals, Iran Polymer and Petrochemicals Institute, PO Box 14975-112, Tehran, Iran;2. Department of Chemistry, School of Science, Alzahra University, PO Box 1993891176, Vanak, Tehran, Iran;3. Department of Chemistry, University of Guilan, Rasht, Iran |
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| Abstract: | Ultrasound irradiation was applied for the rapid and clean synthesis of 3-methyl-4-arylmethylene isoxazole-5(4H)-ones through condensation of hydroxylamine hydrochloride, ethyl acetoacetate and benzaldehyde derivatives. This methodology was effectively catalyzed by amine functionalized montmorillonite K10 nanoclay (NH2-MMT). Compared with conventional methods, this protocol has promising features for the reaction response such as shorter reaction times, easier work-up, ease of separation of pure product with high yields and simplicity in the experimental procedure. |
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