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Activation of aryl chlorides in water for Suzuki coupling with a hydrophilic salen-Pd(II) catalyst
Affiliation:1. Department of Epileptology, University of Bonn, Sigmund-Freud-Straße 25, 53127 Bonn, Germany;2. Department of Neuropathology, University of Bonn, Sigmund-Freud-Straße 25, 53127 Bonn, Germany;3. Department of Nuclear Medicine, University of Bonn, Sigmund-Freud-Straße 25, 53127 Bonn, Germany
Abstract:For exploiting aqueous condition, we have designed a simple water-soluble palladium Schiff-base catalyst for Suzuki-Miyaura reactions of aryl halides with arylboronic acids. The reactions could be performed in neat water with aryl bromides and iodides at room temperature and with aryl chlorides at 100 °C. Good-to-excellent yields of cross-coupling products were obtained with a diverse range of aryl halides including heteroaryl halides. Interestingly, the homogeneous catalyst could be conveniently recycled with aryl bromides or chlorides for at least four times, although a progressive decrease in the product yields were noticed.
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