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Initial power measurements for a family of novel vertical-wheel bioreactors |
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| Authors: | Matthew S. Croughan Daniel Giroux Omokhowa M. Agbojo Erica McCain Nathan Starkweather Samantha Guerra Yas Hashimura Brian Lee Sunghoon Jung |
| Affiliation: | 1. Tahoe Biotechnology LLC, Reno, Nevada, USA Contribution: Data curation, Formal analysis, Investigation, Methodology, Supervision, Validation, Visualization, Writing - original draft, Writing - review & editing;2. Abzena, San Diego, California, USA Contribution: Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing - original draft;3. PBS Biotech Inc., Camarillo, California, USA Contribution: Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing - review & editing;4. PBS Biotech Inc., Camarillo, California, USA Contribution: Data curation, Formal analysis;5. Apeel Sciences, Goleta, California, USA Contribution: Data curation, Formal analysis;6. PBS Biotech Inc., Camarillo, California, USA Contribution: Conceptualization, Investigation;7. PBS Biotech Inc., Camarillo, California, USA Contribution: Funding acquisition, Project administration, Resources, Supervision;8. PBS Biotech Inc., Camarillo, California, USA |
| Abstract: | The purpose of this investigation was to develop an initial set of Power number versus Reynolds number results for a family of vertical-wheel bioreactors. These bioreactors are increasingly being used for the manufacture of cells for cell therapy but have not been characterized according to this approach. A novel gravimetric method to measure power was used, and the validity of this method was assessed by measuring power for a standard stirred tank bioreactor with a Rushton impeller. The results of the gravimetric method were found to closely match those derived from traditional methods. The validated method was then used to measure the power draw and develop an initial set of Power number versus Reynolds number results for a family of vertical-wheel bioreactors. |
| Keywords: | Power number Reynolds number vertical-wheel bioreactor |