Voltage controlled nano-injection system for single-cell surgery |
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Authors: | R Adam Seger Paolo Actis Catherine Penfold Michelle Maalouf Boaz Vilozny Nader Pourmand |
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Affiliation: | Department of Biomolecular Engineering, University of California Santa Cruz, 1156 High Street, Santa Cruz, CA 95064, USA. pourmand@soe.ucsc.edu. |
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Abstract: | Manipulation and analysis of single cells is the next frontier in understanding processes that control the function and fate of cells. Herein we describe a single-cell injection platform based on nanopipettes. The system uses scanning microscopy techniques to detect cell surfaces, and voltage pulses to deliver molecules into individual cells. As a proof of concept, we injected adherent mammalian cells with fluorescent dyes. |
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