A new approach for measuring the trabecular bone density through the echosound backscattering: An ex vivo validation on human femoral heads |
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| Affiliation: | 1. Echolight Srl, Lecce, Italy;2. National Research Council, Institute of Clinical Physiology, Lecce, Italy;3. ENEA, Materials Technology Unit, Research Centre of Brindisi, Brindisi, Italy;1. Department of Civil and Environment Engineering, Worcester Polytechnic Institute (WPI), Worcester, MA 01609-2280, USA;2. Department of Civil and Environmental Engineering, The University of Louisville, Louisville, KY 40292, USA;3. Department of Electrical and Computer Engineering, Texas Tech University, Lubbock, TX 79409-3102, USA;4. Department of Architectural Engineering, Yonsei University, Seoul, 120-749, South Korea;1. Faculty of Science and Industrial Technology, Prince of Songkla University, Surat Thani Campus, Mueang, Surat Thani 84100, Thailand;2. Department of Natural Resource Ecology & Management, Oklahoma State University, Stillwater, OK 74078-6013, USA;1. KIIT University, Bhubaneswar, India;2. Siksha O Anusandhan University, Bhubaneswar, India;3. BITS, Dubai, United Arab Emirates |
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| Abstract: | The aim of this paper was to propose a novel approach to the ultrasound (US) characterization of human bones through an improved measurement of the apparent integrated backscatter (AIB). Four intact human femoral heads were studied ex vivo in their physiologic morphological configuration, including cartilaginous, cortical and trabecular regions. Each sample underwent an US acquisition performed with a clinically-available echographic device and a micro-computed tomography (micro-CT) scan, whose spatial resolution was preliminarily optimized for this specific purpose. A dedicated US signal compensation was employed in the AIB computation, to take into account the variability of sample-probe distance and cortical bone thickness. Obtained results showed an appreciable global correlation between AIB and the trabecular bone volume fraction as quantified by the micro-CT parameter BV/TV (|r| = 0.69). The proposed approach has interesting perspectives for a clinical translation as an innovative method for in vivo US measurement of proximal femur bone density. |
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| Keywords: | Ultrasound signal processing Apparent integrated backscatter Micro-CT Bone volume fraction Femoral head |
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