| 新型除草剂氟丁酰草胺的合成研究 |
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| 引用本文： | 刘安昌,沈乔,周青,姚珊,陈涣友.新型除草剂氟丁酰草胺的合成研究[J].现代农药,2012,11(2):21-22,27. |
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| 作者姓名： | 刘安昌 沈乔 周青 姚珊 陈涣友 |
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| 作者单位： | 武汉工程大学绿色化工过程省部共建教育部重点实验室,湖北省新型反应器与绿色化学工艺重点实验室,武汉430074 |
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| 摘 要： | 以邻氟三氟甲苯等为初始原料,经硝化、还原、重氮化、水解得到4-氟-3-三氟甲基苯酚,然后与烷基化剂2-溴丁酸乙酯反应,得到2-(4-氟-3-三氟甲基苯氧基)丁酸乙酯,再与苄胺发生酰化反应,得到目标产物氟丁酰草胺,总收率52.3%。
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| 关 键 词： | 氟丁酰草胺 除草剂 合成 |
Synthetic Process of Novel Herbicide Beflubutamid |
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| LIU An-chang
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SHEN Qiao
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ZHOU Qing
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YAO Shan
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CHEN Huan-you.Synthetic Process of Novel Herbicide Beflubutamid[J].Modern Agrochemicals,2012,11(2):21-22,27. |
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| Authors: | LIU An-chang SHEN Qiao ZHOU Qing YAO Shan CHEN Huan-you |
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| Affiliation: | (Hubei Novel Reactor & Green Chemical Technology Key Laboratory,Key Laboratory for Green Chemical Process of Ministry of Education,Wuhan Institute of Technology,Wuhan 430074,China) |
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| Abstract: | 4-Fluoro-3-trifluoromethylnitrobenzene was synthesized by nitrification reaction of 2-fluorobenzotrifluoride using sulfuric acid and nitric acid,then it was reduced by hydrazine hydrate to give 4-fluoro-3-trifluoromethylaniline.In the solution of concentrated H2SO4,4-fluoro-3-trifluoromethylaniline was diazotized and hydrolyzed to give 4-fluoro-3-trifluoromethylphenol.Ethyl 2-bromobutyrate reacted with 4-fluoro-3-trifluoromethylphenol to give ethyl 2-(4-fluoro-3-trifluoromethylphenoxy) butyrate,then it reacted with benzylamine to give the target compound beflubutamid.The total yield is 52.3%. |
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| Keywords: | beflubutamid herbicide synthesis |
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