| 小鼠尿中沙美特罗及其代谢物的LC/MS研究 |
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| 引用本文： | 徐友宣,秦旸,刘欣,张亦农,张建丽,吴侔天,朱绍棠.小鼠尿中沙美特罗及其代谢物的LC/MS研究[J].质谱学报,2003,24(3):417-417. |
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| 作者姓名： | 徐友宣 秦旸 刘欣 张亦农 张建丽 吴侔天 朱绍棠 |
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| 作者单位： | 国家体育总局运动医学研究所兴奋剂检测中心,北京,100029 |
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| 摘 要： | 采用较大剂量小鼠灌胃给药 ,得到的尿样经固相提取后用 LC/ APCI/ MS分析 ,根据代谢知识及比较空白尿和阳性尿的响应数据 ,得出了沙美特罗的原型和四种代谢产物。结果表明 :小鼠尿中沙美特罗可能的主要代谢途径为羟基化、甲氧基化以及两者的加合。
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| 关 键 词： | 质谱学 沙美特罗及其代谢物研究 LC/MS β2-激动剂 大气压化学电离(APCI) |
| 文章编号： | 1004-2997(2003)02-417-04 |
| 收稿时间： | 2002-11-26 |
| 修稿时间： | 2002年11月26 |
Determination of Salmeterol and Its Metabolites in Rat Urine by LC/MS |
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| XU You-xuan,QIN Yang,LIU Xin,ZHANG Yi-nong,ZHANG Jian-li,WU Mou-tian,ZHU Shao-tang.Determination of Salmeterol and Its Metabolites in Rat Urine by LC/MS[J].Journal of Chinese Mass Spectrometry Society,2003,24(3):417-417. |
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| Authors: | XU You-xuan QIN Yang LIU Xin ZHANG Yi-nong ZHANG Jian-li WU Mou-tian ZHU Shao-tang |
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| Abstract: | 15 mg of salmeterol is administrated to 10 rats, which weighs about 25 g each. The urine of the rats is extracted by solid-phase column and analyzed by liquid chromatography-APCI-mass spectrometry. Parent drug and four metabolites are identified by comparing total ion chromatograms of the blank with the metabolic urine as well as their mass spectra. Its main metabolic pathways are the hydroxylation and/or methoxylation from the experiments. |
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| Keywords: | LC/MS |
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