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| 溶析结晶提纯阿维菌素 | |
| 引用本文： | 吴送姑,刘甜甜,董伟兵,龚俊波. 溶析结晶提纯阿维菌素[J]. 农药, 2011, 50(9) |
| 作者姓名： | 吴送姑 刘甜甜 董伟兵 龚俊波 |
| 作者单位： | 1. 天津大学化工学院国家工业结晶工程技术研究中心,天津,300072 2. 天津大学现代药物传递及功能高效化天津市重点实验室,天津,300072 3. 天津大学化工学院国家工业结晶工程技术研究中心,天津300072;天津大学现代药物传递及功能高效化天津市重点实验室,天津300072 |
| 基金项目： | 天津市自然科学基金(09JCZDJC2011,10JCYBJC14200); 国家自然科学基金(30900540) |
| 摘 要： | [目的]工业中要通过多次重结晶提纯阿维菌素才能得到纯度较高的产品,生产成本大.提出阿维菌素提纯的溶析结晶工艺,减少操作成本.[方法]通过高效液相色谱法和显微镜观察法考察不同溶剂和溶析剂对产品纯度、杂质含量以及产品晶习的影响.[结果]通过1次溶析结晶产品B1纯度可以达到95％以上.得到的产品一般是粒状或者棱柱状.[结论]乙酸乙酯为溶剂、乙醇为溶析剂得到的产品B1纯度最高,而丙酮作溶剂、水为溶析剂对某些杂质有更好的去除效果.溶析结晶得到的产品一般是粒状或者棱柱状,相对冷却结晶得到的针状晶体有利于后续过滤、洗涤、干燥等过程. |
| 关 键 词： | 阿维菌素 溶析结晶 纯度 晶习 |
Purification of Avermectins by Solvent-out Crystallization |
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| WU Song-gu , LIU Tian-tian , DONG Wei-bing , GONG Jun-bo. Purification of Avermectins by Solvent-out Crystallization[J]. Pesticides, 2011, 50(9) | |
| Authors: | WU Song-gu LIU Tian-tian DONG Wei-bing GONG Jun-bo |
| Affiliation: | WU Song-gu1,LIU Tian-tian1,dong wei-bing2,GONG Jun-bo1,2(1.The State Research Center of Industrialization for Crystallization Technology,School of Chemical Engineering and Technology,Tianjin University,Tianjin 300072,China,2.Key Laboratory Modern Drug Delivery and High Efficiency in Tianjin University,China) |
| Abstract: | Three or more recrystallizations are needed to get the final products of avermetins,leading to high cost in industry.Solvent-out crystallization of avermectins was proposed to reduce the cost.[Methods] The effect of solvent/anti-solvent on the product purity,impurity content and crystal habits was investigated by high performance liquid chromatography and microscope.[Results] B1 content of avermectins product reached 95% by one step solvent-out crystallization,the products are generally prismatic or granula... |
| Keywords: | avermectins solvent-out crystallization purity crystal habit |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |