| 极性氨基酸甲酯盐酸盐合成新方法 |
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| 引用本文： | 陆晓青,赵干卿,宋霞,谢吉民.极性氨基酸甲酯盐酸盐合成新方法[J].化学世界,2007,48(6):357-359. |
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| 作者姓名： | 陆晓青 赵干卿 宋霞 谢吉民 |
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| 作者单位： | 江苏大学化学化工学院,江苏,镇江,212013 |
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| 基金项目： | 江苏省社会发展基金资助课题(BS2006038) |
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| 摘 要： | 以四种极性氨基酸、二氯亚砜和HCl的甲醇溶液为原料合成了L-酪氨酸甲酯盐酸盐,L-蛋氨酸甲酯盐酸盐,L-丝氨酸甲酯盐酸盐,L-赖氨酸甲酯盐酸盐四种稳定的氨基酸甲酯盐酸盐,并通过元素分析、红外光谱对化合物的组成和结构进行了表征。反应条件温和,产率较高,产率高达95.4%~97.5%;同时也讨论了影响反应的因素。
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| 关 键 词： | 氨基酸甲酯盐酸盐 氨基酸 合成 |
| 文章编号： | 0367-6358（2007）06-357-03 |
| 修稿时间： | 2006-07-262006-08-25 |
A Novel Method of Synthesis of Polar Amino Acid Methyl Ester Hydrochlorides |
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| LU Xiao-qing,ZHAO Gan-qing,SONG Xia,XIE Ji-min.A Novel Method of Synthesis of Polar Amino Acid Methyl Ester Hydrochlorides[J].Chemical World,2007,48(6):357-359. |
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| Authors: | LU Xiao-qing ZHAO Gan-qing SONG Xia XIE Ji-min |
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| Affiliation: | School of Chemistry and Chemical Engineering, Jiangsu University, Jiangsu Zhenjiang 212013, China |
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| Abstract: | L-Tyrosine methyl ester hydrochloride, L-methionine methyl ester hydrochloride, L-serine methyl ester hydrochloride and Dlysine methyl ester hydrochloride were synthesized by reacting amino acids with HCl in methanol in the presence of thionyl chloride. The compositions and structures of these compounds were characterized by elemental analysis and IR spectoscopy. The reaction conditions were mild, and the yields reached 95.4% -97.5%. The factors affecting the reactions were also discussed. |
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| Keywords: | amino acid methyl ester hydrochloride amino acid synthesis |
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