| 绿色环保溶剂在5-乙硫基-1H-四氮唑制备上的应用 |
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| 引用本文： | 李永伟,聂新永,田金如,刘玉真. 绿色环保溶剂在5-乙硫基-1H-四氮唑制备上的应用[J]. 化学世界, 2007, 48(8): 478-479,510 |
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| 作者姓名： | 李永伟 聂新永 田金如 刘玉真 |
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| 作者单位： | 河北科技大学化学与制药工程学院,河北,石家庄,050018;河北科技大学化学与制药工程学院,河北,石家庄,050018;河北科技大学化学与制药工程学院,河北,石家庄,050018;河北科技大学化学与制药工程学院,河北,石家庄,050018 |
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| 摘 要： | 以水为溶剂,少量乙醇作增溶剂合成5-乙硫基-1H-四氮唑。对影响反应收率的溶剂配比、反应温度、反应时间及物料配比各因素进行了研究,确定了反应的最佳条件,总收率达83.5%,反应物料的用量大大降低。
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| 关 键 词： | 无水乙醇 硫氰酸乙酯 5-乙硫基-1H-四氮唑 合成 |
| 文章编号： | 0367-6358（2007）08-478-02 |
| 修稿时间： | 2006-04-032006-08-25 |
Application of Environmentally Benign Solvent in Synthesis of 5-Ethylthio-1H-tetrazole |
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| LI Yong-wei,NIE Xin-yong,TIAN Jin-ru,LIU Yu-zhen. Application of Environmentally Benign Solvent in Synthesis of 5-Ethylthio-1H-tetrazole[J]. Chemical World, 2007, 48(8): 478-479,510 |
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| Authors: | LI Yong-wei NIE Xin-yong TIAN Jin-ru LIU Yu-zhen |
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| Affiliation: | Hebei University of Science and Technique College of Chemical and Pharmaceutical, Hebei Shijiazhuang 050018, China |
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| Abstract: | 5-Ethylthio-1H-tetrazole was synthesized using water as solvent and absolute ethanol as cosolvent.The factors affection the reaction were investigated,including the solvent proportion,reaction temperature,reaction time and reagent proportion.The most suitable conditions were obtained.Compared to traditional methods,the amount of reagent was reduced largely.The product yield was 83.5%. |
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| Keywords: | absolute ethanol ethyl thiocyanate 5-ethylthio-1H-tetrazole synthesis |
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