阿司匹林壳聚糖纳米缓释微球的制备及体外释放性能的研究

以自制阿司匹林为药物,壳聚糖为载体,采用乳化-化学交联法制备了阿司匹林-壳聚糖载药微球,确定了阿司匹林-壳聚糖载药微球的制备工艺条件,探讨搅拌速度、阿司匹林/壳聚糖质量比、交联剂戊二醛、乳化剂Span-80用量对微球的药物包封率、载药量和释药性能的影响。研究结果表明,室温条件下,以液体石蜡为介质,选用3%的壳聚糖冰醋酸溶液、按阿司匹林∶壳聚糖=1.5∶1、4%的戊二醛为交联剂、Span-80用量为体积比6%、中等搅拌速度制备出的微球药物包封率可达79%,微球粒径最小可达20 nm,制得的载药微球在16 h内对药物有良好的缓释作用,在25 h之内仍存在缓药效果。

Preparation and in Vitro Releasing Property of Aspirin-Chitosan Sustained-Release Nanometer Microsphere

Aspirin-chitosan microspheres were prepared by emulsion-chemical crosslink using chitosan as carrier and aspirin as a drug.The preparation conditions of aspirin-chitosan microspheres were studied.The effects of stirring rate,aspirin/chitosan,glutaraldehyde and Span-80 on the incorporation rate,the loading of drug and the drug release behavior of the prepared microspheres were discussed.Under ambient temperature conditions,liquid paraffin was used as the medium.When the concentration of chitosan was 3%,aspirin/chitosan was 1.5,the dosage of glutaraldehyde was 4%,the dosage of span-80 was 6% of the total volume,and the stiring rate was 20 r/min.the incorporation rate of the microspheres reached 79%,and the diameter of the microspheres was no larger than 20 nm.The vitro release of the microsphere indicated that it had satisfactory sustained releasing behavior for the drug within 16 h,and the sustained release behavior still exists within 25 h.