肠道病毒71型基因重组的研究进展

肠道病毒71型(Enterovirus 71,EV71)是手足口病(Hand,foot and mouth disease,HFMD)的主要病原体,属于肠道小RNA病毒,这类病毒的基因组由脆性平链RNA组成,易断裂,有较高的突变性。在混合感染中会发生同型不同株不同亚型,或同属不同型间的基因交换形成新的重组病毒,EV71也具有重组特性。新形成的重组病毒可能导致其生物学特性和致病性的改变,进而影响疾病的防控。本文就EV71病毒基因重组及可能引发的防控问题进行综述。

Progress in research on gene recombination of enterovirus 71

As the major pathogen of hand,foot and mouth disease(HFMD),enterovirus 71(EV71)belongs to enteric small RNA virus.The genomes of this kind of viruses consist of friable flat chain RNAs which show high mutagenicity and are easy to be broken.In mixed infection,novel recombinant viruses may formed by gene exchange between different strains or subtypes of the same type,or between the different types of the same genus,which may result in the change of biological characters and pathogenesis of the viruses,thus influence the prevention and control of relevant diseases.The paper attempts to give a review on EV71 gene recombination as well as the resulted problems in prevention and control of the virus.