Effect of soft segment length on properties of hydrophilic/hydrophobic polyurethanes |
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| Authors: | Yung‐Hsin Lin Nai‐Kuan Chou Kuan‐Fu Chen Guan‐Huei Ho Chih‐Hao Chang Shoei‐Shen Wang Shu‐Hsun Chu Kuo‐Huang Hsieh |
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| Affiliation: | 1. Department of Chemical Engineering, National Taiwan University, Taipei, Taiwan;2. Department of Surgery, College of Medicine, National Taiwan University Hospital, Taipei, Taiwan;3. Institute of Polymer Science and Engineering, National Taiwan University, Taipei, Taiwan;4. Department of Orthopedics, National Taiwan University Hospital, Taipei, Taiwan;5. Far Eastern Memorial Hospital, Taipei, Taiwan;6. Institute of Polymer Science and Engineering, National Taiwan University, Taipei, TaiwanDepartment of Chemical Engineering, National Taiwan University, Taipei, Taiwan |
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| Abstract: | Polyurethanes (PUs) were prepared from 4,4′‐diphenylmethane diisocyanate and various molecular weights of poly(tetramethylene glycol) and polydimethylsiloxane. The physical properties of these polymers were determined using Fourier transform infrared spectroscopy and through calculation of their swelling ratios. The thermal properties were investigated through thermogravimetric analysis and dynamic mechanical analysis. The blood compatibility of each polymer was determined by calculating its relative index of platelet adhesion (RIPA). Domain separation of the resulting PUs occurred during polymerization because of the immiscibility of the hydrophilic and hydrophobic polyols. The hydrophilic/hydrophobic domain‐separated structure affected the surface tension through the formation of hydrophilic and hydrophobic domains of the PU, which reduced the adhesion of blood platelets onto the materials. The PU(PDMS/PTMO1000) = 75/25 sample, with its RIPA of 0.34, appears to be suitable for biomedical applications as a blood‐compatible material. Copyright © 2007 Society of Chemical Industry |
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| Keywords: | polyurethane domain separation hydrophilic/hydrophobic relative index of platelet adhesion (RIPA) |
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