吡唑醚菌酯的合成研究 |
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引用本文: | 李清,李巍,刘东志,周雪琴.吡唑醚菌酯的合成研究[J].化学工业与工程,2016,33(1):45-50. |
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作者姓名: | 李清 李巍 刘东志 周雪琴 |
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作者单位: | 天津大学化工学院, 天津 300072 |
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摘 要: | 以邻硝基甲苯为原料,经还原、酰化、甲基化和溴化四步反应得到N-甲氧基-N-2-溴甲苯氨基甲酸甲酯,然后与1-(4-氯苯基)-3-吡唑醇反应得到吡唑醚菌酯。在优化后的反应条件下,目标化合物纯度大于98.4%(LC),总收率大于56.7%(以邻硝基甲苯计),其结构经1H-NMR和MS分析确证。该工艺具有反应条件温和,产品收率高等优点,适合工业化生产。
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关 键 词: | 吡唑醚菌酯 邻硝基甲苯 1-(4-氯苯基)-3-吡唑醇 合成 |
Synthesis of Pyraclostrobin |
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Affiliation: | School of Chemical Engineering and technology, Tianjin University, Tianjin 300072 |
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Abstract: | Pyraclostrobin was synthesized by reaction of methyl N-methoxyl-N-2-bromine toluene carbamate with 1-(4-chlorophenyl)-3-hydroxypyrazole, methyl N-methoxyl-N-2-bromine toluene carbamate was prepared from o-nitrotoluene by reduction, acylation, methylation, and bromination four steps. Under the optimal condition, the purity was 98.4%(LC), and the total yield was 56.7% based on o-nitrotoluene. The structure of the prepared product was confirmed by 1H-NMR and MS. The process exhibites mild reaction conditions and high yield, and is suitable for industrial production. |
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Keywords: | pyraclostrobin o-nitrotoluene o-nitrotoluene" target="_blank">')" href="#">o-nitrotoluene 1-(4-chlorophenyl)-3-hydroxypyrazole synthesis |
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