Effects of an ionophore, X-537A, on mouse CNS cultures: a light and electron microscope study |
| |
Authors: | AR Tessler SU Kim NK Gonatas |
| |
Abstract: | The effects of the ionophore X-537A on organotypic CNS tissue culture were investigated with bright field and electron microscopy. In addition to condensation of mitochondria this agent was found to induce a relatively selective vacuolation of the Golgi apparatus of neurons and glial cells. At the dosages used (50 mug/ml for 2-3 hours and 100 mug/ml for 1 hour) these changes were irreversible. Additional experiments suggested that the cellular effects of X-537A were primarily due to its ability to translocate Na+ across cellular membranes. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|