| L-脯氨酸不对称催化合成二乙基2-（2-氰乙基）丙二酸 |
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| 引用本文： | 刘正堂. L-脯氨酸不对称催化合成二乙基2-（2-氰乙基）丙二酸[J]. 精细化工, 2010, 27(6) |
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| 作者姓名： | 刘正堂 |
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| 作者单位： | 1. 兰州大学,化学化工学院,甘肃,兰州,730000
2. 兰州理工大学,材料与工程学院,甘肃,兰州,730050 |
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| 摘 要： | 以L-脯氨酸为催化剂,丙二酸二乙酯和丙烯腈为原料,经迈克尔加成反应合成了二乙基2-(2-氰乙基)丙二酸。并研究了反应条件对产物产率及对映体过量值(ee)的影响。结果表明,以吡啶为溶剂,丙二酸二乙酯0.1mol,丙烯腈0.12mol,L-脯氨酸0.04mol,反应温度35℃,反应时间48h的条件下,二乙基2-(2-氰乙基)丙二酸的产率及对映体过量值(ee)分别为74.10%和79%。
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| 关 键 词： | 二乙基2-(2-氰乙基)丙二酸 L-羟脯氨酸 迈克尔加成反应 丙烯腈 丙二酸二乙酯 催化与分离提纯技术 |
| 收稿时间： | 2010-01-06 |
| 修稿时间： | 2010-03-01 |
Synthesis of Diethyl 2-(2-cyanoethyl) malonate Catalyzed by L-Proline |
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| LIU Zheng-tang. Synthesis of Diethyl 2-(2-cyanoethyl) malonate Catalyzed by L-Proline[J]. Fine Chemicals, 2010, 27(6) |
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| Authors: | LIU Zheng-tang |
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| Affiliation: | Northern Coatings Industry Research & Design Institute |
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| Abstract: | Diethyl 2-(2-cyanoethyl)malonate was synthesized from diethyl malonate and acrylonitrile by the Michael addition reaction using L-proline as catalyst.The effects of the reaction condition on the yield and the enantiomeric excess value of diethyl 2-(2-cyanoethyl)malonate were investigated.74.10% yield with 79% enantiomeric excess value was obtained under the optimal reaction conditions:pyridine as solvent;the dosage of diethyl malonate,0.1 mol;the mole ratio of diethyl malonate to acrylonitrile,1∶1.2;the dosage of L-proline,0.04 mol;reaction time 48 h and temperature 35 ℃,respectively. |
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| Keywords: | Diethyl 2-(2-cyanoethyl)malonate L-Proline Michael addition reaction acrylonitrile diethyl malonate |
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