Using constraints and their value for optimization of large ODE systems |
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Authors: | Mirela Domijan David A Rand |
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Affiliation: | 1.Sainsbury Laboratory, University of Cambridge, Cambridge CB2 1LR, UK;2.Warwick Systems Biology Centre and Mathematics Institute, University of Warwick, Coventry CV4 7AL, UK |
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Abstract: | We provide analytical tools to facilitate a rigorous assessment of the quality and value of the fit of a complex model to data. We use this to provide approaches to model fitting, parameter estimation, the design of optimization functions and experimental optimization. This is in the context where multiple constraints are used to select or optimize a large model defined by differential equations. We illustrate the approach using models of circadian clocks and the NF-κB signalling system. |
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Keywords: | systems biology models experimental optimization statistical estimation circadian clocks signalling systems |
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