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New polyester biodegradable scaffolds for chondrocyte culturing: Preparation,properties, and biological activity |
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| Authors: | Agnieszka Gadomska-Gajadhur Aleksandra Kruk Judyta Dulnik Andrzej Chwojnowski |
| Affiliation: | 1. Faculty of Chemistry, Warsaw University of Technology, Warsaw, Poland;2. Faculty of Chemistry, Warsaw University of Technology, Warsaw, Poland Faculty of Pharmacy, Medical University of Warsaw, Warsaw, Poland;3. Institute of Fundamental Technological Reserch PAS, Warsaw, Poland;4. Nałęcz Institute of Biocybernetics and Biomedical Engineering PAS, Warsaw, Poland |
| Abstract: | An innovative modification of the wet inversion phase method, consisting in the use of a polymer nano-nonwoven as a nonclassic pore precursor. Mechanical properties of the obtained scaffolds were determined, their hydrophilic properties (serum absorbability) were tested, and the content of residues of materials used in the scaffold preparation was determined. Nontoxicity of the developed scaffolds toward T lymphocyte cells was proved. Cultures of primary chondrocytes were obtained successfully. It was proved that an addition of a polymer nano-nonwoven changes the properties of the scaffolds favorably in respect of their subsequent application in tissue engineering. |
| Keywords: | cartilage regeneration chondrocytes nano-nonwoven polyvinylpyrrolidone T lymphocytes |