| Affiliation: | 1. Key Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University), Ministry of Education, School of Materials and Energy, Southwest University, Chongqing, China;2. Key Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University), Ministry of Education, School of Materials and Energy, Southwest University, Chongqing, China Beijing Key Laboratory for Magnetoelectric Materials and Devices, Beijing Innovation Center for Engineering Science and Advanced Technology, Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing, China;3. Beijing Key Laboratory for Magnetoelectric Materials and Devices, Beijing Innovation Center for Engineering Science and Advanced Technology, Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing, China;4. Chongqing Youth Vocational and Technical College, Chongqing, China |
| Abstract: | Photothermal-enhanced chemodynamic therapy is a novel and promising strategy for effective tumor treatment. Herein, a kind of polydopamine (PDA)-based nanoplatform is reported for photothermal-enhanced chemodynamic therapy against tumor cells. PDA nanoparticles (NPs) were prepared through the self-polymerization method, which were subsequently chelated with Cu2+ and linked with poly(ethylene glycol) (PEG) chains, finally obtaining PDA-Cu(II)-PEG NPs. The fabricated PDA-Cu(II)-PEG NPs were uniform in shape with a narrow polydispersity. They can firstly react with glutathione (GSH) to generate Cu+, inducing GSH depletion meanwhile. The formed Cu+ could catalyze H2O2 to produce hydroxyl radicals (˙OH) via a Fenton-like reaction. The formed PDA-Cu(II)-PEG NPs displayed good photothermal conversion efficiency and photothermal stability. They can be internalized by 4T1 cells effectively. Under near-infrared light irradiation, PDA-Cu(II)-PEG NPs can generate hyperthermia and ˙OH for photothermal/chemodynamic therapy against tumor cells. |
