Characterization of CS/PVA/GO electrospun nanofiber membrane with astaxanthin |
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| Authors: | Hengfang Zhang Lexun Lin Liping Ren Yongxu Liu Rong Song |
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| Affiliation: | 1. First Affiliated Hospital of Harbin Medical University, College of Stomatology, Harbin Medical University, Harbin, China;2. Department of Pathogenic Microbiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China;3. Institute of Materials Science and Engineering, Northeast Forestry University, Harbin, China |
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| Abstract: | Tissue engineering has been widely used in regenerative medicine and tissue engineering scaffolds have become a new research direction for periodontal regenerative repair. We aim to develop a biological scaffold material that can support host immunity and promote periodontal regeneration. In this paper, chitosan (CS)/polyvinyl alcohol (PVA)/graphene oxide (GO)/astaxanthin (ASTA) nanofibers membranes were prepared by electrospinning. The nanofibers were characterized by scanning electron microscopy, infrared spectroscopy, mechanical testing, antibacterial testing and cytotoxicity testing. The CS/PVA/GO/ASTA nanofiber membrane had favorable micro-morphology, good mechanical properties and no cytotoxicity. This preliminary study demonstrates that the CS/PVA/GO/ASTA nanofiber membrane can be used for in vivo and in vitro experiments related to periodontal regeneration. The related mechanism of periodontal regeneration will be evaluated in future studies. |
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| Keywords: | astaxanthin (ASTA) cytocompatibility electrospinning graphene oxide (GO) nanofiber membrane |
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