A poly(L-lactic acid) monofilament with high mechanical properties for application in biodegradable biliary stents |
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| Authors: | Yuan Tian Jing Zhang Jie Cheng Gensheng Wu Yi Zhang Zhonghua Ni Gutian Zhao |
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| Affiliation: | 1. School of Mechanical Engineering, Jiangsu Key Laboratory for Design and Manufacture of Micro-Nano Biomedical Instruments, Southeast University, Nanjing, China;2. School of Mechanical and Electronic Engineering, Nanjing Forestry University, Nanjing, China;3. Center of Interventional Radiology & Vascular Surgery, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, Nanjing, China |
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| Abstract: | In this article, a poly(L-lactic acid) (PLLA) monofilament with high mechanical properties which can be used to construct biodegradable biliary stents (BBS) is prepared. Compared with a commercial polydioxanone (PDO) suture, the PLLA monofilament has much higher Young's modulus. As a result, chronic outward force (COF) of the stent braided by PLLA monofilament is more than three times higher than that of the stent braided by PDO suture. Furthermore, by physicochemical indexes characterizations, it is acceptable that the PLLA monofilament has stable Young's modulus and higher elongation at break without brittle fracture risk during degradation in bile. In contrast, although PDO suture can also maintain Young's modulus well during degradation, its elongation at break is attenuated rapidly, which shows a high brittle fracture risk. These results indicate that PLLA monofilament is more suitable for constructing BBS with high COF, which are promising in treating more complex biliary strictures that need longer support time. |
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| Keywords: | biodegradable biliary stents biomedical applications mechanical properties poly(L-lactic acid) monofilament |
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