Thermal and dynamic mechanical behavior of poly(lactic acid) (PLA)-based electrospun scaffolds for tissue engineering |
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Authors: | Nicola Ciarfaglia Antonio Laezza Louise Lods Antoine Lonjon Jany Dandurand Antonietta Pepe Brigida Bochicchio |
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Affiliation: | 1. CIRIMAT, Physique des polymères, Université Paul Sabatier, Toulouse, France
Laboratory of Bioinspired Materials, Università degli Study della Basilicata, Potenza, Italy;2. Laboratory of Bioinspired Materials, Università degli Study della Basilicata, Potenza, Italy;3. CIRIMAT, Physique des polymères, Université Paul Sabatier, Toulouse, France |
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Abstract: | Electrospun scaffolds can find numerous applications, including biomedical; for example, tissue engineering. Poly-L-lactic acid is considered suitable for these applications, but its low-thermal stability and its poor mechanical properties limit this polymer use. The aim of this work is to obtain a modulation of the final scaffolds characteristics such as fibers dimension, wettability, elasticity, and resistance to rupture through the choice of the polymers to be electrospun. Different electrospun scaffolds containing gelatin, Poly-DL-lactic acid, different percentages of cellulose nanocrystals and an elastin peptide have been produced. Thermal stability, physical structure, and its mechanical behavior have been studied. Results suggest that the electrospun scaffolds show better thermal and mechanical properties than bulk materials; that is, the scaffolds with the best hydrophilic and thermomechanical properties are the samples containing 3% (wt/wt) of CNCs and elastin peptide. |
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Keywords: | biomaterials degradation differential scanning calorimetry fibers mechanical properties |
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