| 非硝基化合物S-8712对离体培养细胞放射增敏作用研究 |
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| 引用本文： | 糜福顺,李政,沈瑜,胡璧,王荣先,李美佳,放培基.非硝基化合物S-8712对离体培养细胞放射增敏作用研究[J].辐射研究与辐射工艺学报,1990(2). |
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| 作者姓名： | 糜福顺 李政 沈瑜 胡璧 王荣先 李美佳 放培基 |
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| 作者单位： | 中国医学科学院肿瘤研究所 北京
(糜福顺，李政，沈瑜)，中国医学科学院放射医学研究所 天津
(胡璧，王荣先，李美佳)，中国医学科学院放射医学研究所 天津(放培基) |
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| 基金项目： | “七五”医学国家重点科技攻关项目 |
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| 摘 要： | 以离体培养HeLa细胞存活曲线研究了S-8712对乏氧细胞放射增敏效果。实验结果表明浓度为2m mol/L时,以D_0和D_q分别计算所得增敏比(SER)为1.04和1.26。6m mol/L的SER则分别为1.35和1.25。该化合物对有氧细胞的亚致死损伤修复有抑制作用,但对有氧细胞放射敏感性没有影响。
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| 关 键 词： | S-8712 乏氧细胞 放射增敏作用 |
STUDIES ON RADIOSENSITIZING EFFECT OF NONNITRO COMPOUND S-8712 IN VITRO |
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| Mi Fushun,Li Zheng,Shen yu,Hu Bi,Wang Rongxian,Li Meijia,Shi Peiji Cancer Institute.STUDIES ON RADIOSENSITIZING EFFECT OF NONNITRO COMPOUND S-8712 IN VITRO[J].Journal of Radiation Research and Radiation Processing,1990(2). |
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| Authors: | Mi Fushun Li Zheng Shen yu Hu Bi Wang Rongxian Li Meijia Shi Peiji Cancer Institute |
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| Abstract: | The radiosensitizing effect of non-nitro compound S-8712 on HeLa-S_3 cell line was investigated, using cell colony forming assay in vitro. When theconcentration of compound was 2 mmol/L, sensitizer enhancement ratio (SER) ofhypoxic cells calculated according to the ratio of D_0 and D~q was 1.04 and 1.26.When the concentration of S-8172 raised to 6 mmol/L SER was 1.35 and 1.25 res-pectively. It showed that the radiosensitizing effect of S-8712 was less then MISO atsame concentratron. The effect of S-8712 was also observed on oxic HeLa-S_3 cells.This compound demonstrated marked inhibition on repair of sublethal damage foraerobic cells. |
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| Keywords: | Non-Nitro Compound Hypoxic cell Radiosensitizing effect |
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