| Synthesis of serotonin transporter imaging agent [^125I]ADAM |
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| 作者姓名： | LUChun-Xiong WUChun-Ying JIANGQuan-Fu CHENZheng-Ping ZHANGTong-Xing LIXiao-Ming WANGSong-Pei |
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| 作者单位： | JiangsuInstituteofNuclearMedicine,Wuxi214063 |
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| 基金项目： | Supported by a grant (RC2002068) from “135” Medicinal Momentous Project of Jiangsu Province and by a grant from Department of Personnel,Jiangsu Province. |
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| 摘 要： | The synthesis of serotonin transporter imaging agent ^125I] -2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine(^125I] ADAM) was reported. The chemical structure of the labeling precursor 5- (tributylstannyl) -2-((2-((dimethylamino)methyl)phenyl)thio)phenylamine and all its intermediates were verified by IR, ^1HNMR and MS. The radioiodinated compound was prepared using iododestannylation reaction by hydrogen peroxide. Final radiochemical purity was above 95% determined by TLC.
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| 关 键 词： | 复合胺传输 成象介质 TLC 合成工艺 放射医学 |
Synthesis of serotonin transporter imaging agent [125I]ADAM |
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| LUChun-Xiong WUChun-Ying JIANGQuan-Fu CHENZheng-Ping ZHANGTong-Xing LIXiao-Ming WANGSong-Pei.Synthesis of serotonin transporter imaging agent [^125I]ADAM[J].Nuclear Science and Techniques,2005,16(3):153-155. |
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| Authors: | LU Chun-Xiong WU Chun-Ying JIANG Quan-Fu CHEN Zheng-ping ZHANG Tong-xing LI Xiao-Ming WANG Song-pei |
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| Abstract: | The synthesis of serotonin transporter imaging agent 125I] -2-((2-((dimethylamino)methyl)phenyl) thio)-5-iodophenylamine(125I] ADAM) was reported. The chemical structure of the labeling precursor 5- (tributyl- stannyl) -2-((2-((dimethylamino)methyl)phenyl)thio)phenylamine and all its intermediates were verified by IR,1HNMR and MS. The radioiodinated compound was prepared using iododestannylation reaction by hydrogen peroxide. Final radiochemical purity was above 95% determined by TLC. |
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| Keywords: | Serotonin transporter [125I] ADAM Synthesis |
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