扁舵鲣鱼低聚肽降尿酸功效评价

该研究以高尿酸血症大鼠模型为对象,来评价扁舵鲣鱼低聚肽(Auxis thazard oligopeptide,ATO)降尿酸功效。结果表明,通过对比模型组、ATO 1.6 g/kg、2.4 g/kg剂量组,发现脏器系数并不存在显著差异。血清黄嘌呤氧化酶(xan-thine oxidase,XOD)的变化趋势为先降后升再缓降,据此可以确定,短时间内肝脏中XOD活性能明显降低。对比模型组可以发现,血清尿素氮、血肌酐指标有所下降,ATO 2.4 g/kg剂量组最为明显,血尿酸含量明显下降,差异有统计学意义(P<0.05)。各试验组的尿酸浓度和尿酸排泄量相比正常组也有明显降低(P<0.05)。依据组织病理学结果可知,通过ATO的应用,能够保护高尿酸血症大鼠的肾脏,但剂效关系尚不明显;尿酸生成因尿酸盐沉积的减少而降低,因而ATO具有一定的降尿酸功效,并且不会产生过多的毒副作用。

Evaluation of Auxis thazard oligopeptides on lowering uric acid

Hyperuricemia rat model was used to evaluate Auxis thazard oligopeptide(ATO)on lowering uric acid.The results showed that there was no significant difference in organ coefficients between 1.6 g/kg and 2.4 g/kg ATO groups compared with model group.Moreover,serum XOD showed a trend of decreasing first and then increasing,finally declining slowly,which indicated that XOD activity in the liver was significantly decreased in a short term.Besides,serum urea nitrogen and serum creatinine showed a downward trend,the blood uric acid content of 2.4 g/kg ATO group decreased significantly(P<0.05).The uric acid concentration and uric acid excretion in each test group were also significantly lower than those in the normal group(P<0.05).Futhermore,histopathological results showed that ATO had a certain protective effect on the kidney of hyperuricemia rats.However,the dose-effect relationship was not significant.Less urate deposition indicated a decrease in uric acid production to some extent.Therefore,ATO has a certain uric acid lowering effect even though with a little toxic side effects.