季铵盐型洗手液的制备及其抗菌性能研究

通过对原料的选择和配方的优化,制备了一种季铵盐型抗菌洗手液。该洗手液配方(以质量分数计)由0.75%十二烷基聚氧乙烯醚硫酸钠(AES),2.25%十四烷基甲基二羟乙基溴化铵(TMDAB),20%椰油酰胺丙基甜菜碱(CAB-35),0.25%醇醚磺基琥珀酸单酯二钠盐(MES),1.5%椰子油二乙醇酰胺(6501),1%甘油,0.1%二羟甲基海因(DMDMH),少量香精及色素,少量柠檬酸调p H和余量的蒸馏水组成。经过测试表明该洗手液对大肠杆菌和金黄色葡萄球菌的杀菌率达到99.99%和100%,产品稳定性、起泡性好,生产成本较低,与市售的某些抗菌洗手液相比,该洗手液显示出一定的优越性。

Preparation and performance of a quaternary ammonium salt based antibacterial hand sanitizer

By selecting and optimizing the formulation of components, a quaternary ammonium salt based antibacterial hand sanitizer was prepared. The formulation (expressed as mass fraction) consists of 0.75% sodium ethoxylated dodecyl alcohol sulfate (AES), 2.25% tetradecylmethyldihydroxyethylammonium bromide (TMDAB), 20% cocamidopropyl betaine (CAB-35), 0.25% disodium ethoxylated alcohol succinic acid monoester sulfonate (MES), 1.5% coconut acid diethanolamide (6501), 1% glycerin, 0.1% dimethylol dimethyl hydantoin (DMDMH), a little amount of fragrance and colorant, as well as a small amount of citric acid for adjusting pH value. The balance is distilled water. Test results of the product showed that the sterilization efficacy for Escherichia coli and Staphylococcus aureus achieves 99.99% and 100% respectively. The product stability and foaming performance are well. Besides, its production cost is rather low. As comparing with some liquid hand cleaners from the market, the prepared product shows somewhat better antibacterial efficacy.