Development and In-Vitro Evaluation of Ethyl Cellulose Micropellets as a Controlled Release Dosage Form for Theophylline |
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Authors: | Biswanath Sa A. K. Bandyopadhyay B. K. Gupta |
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Affiliation: | a Division of Pharmaceutics, Faculty of Engineering and Technology, Department of Pharmacy, Jadavpur University, Calcutta, INDIA |
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Abstract: | A micropellet dosage form was developed using ethyl cellulose as a polymer with a view to achieve a controlled release oral drug delivery system for theophylline. Drugpolymer ratios and stirring speeds were found to influence the size-distribution of micropellets. Time required for 50% release of theophylline from micropellets was found to vary linearly with the drug content and reciprocal of diameter of micropellets. Invitro release of theophylline from micropellets, having different drug-polymer ratios and different sizes, was found apparently to follow both the First-order release and Diffusion controlled release processes. By differential rate treatment it was found that the overall release, in fact, followed diffusion controlled process. |
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