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A high-density multi-point LAPS set-up using a VCSEL array and FPGA control |
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| Authors: | Torsten WagnerAuthor Vitae,Carl Frederik B. WernerAuthor Vitae,Ko-Ichiro MiyamotoAuthor VitaeMichael J. Schö ningAuthor Vitae,Tatsuo YoshinobuAuthor Vitae |
| Affiliation: | a Department of Biomedical Engineering, Tohoku University, Japan b Institute of Nano- and Biotechnologies, Aachen University of Applied Sciences, Germany c Institute of Bio- and Nanosystems-2, Research Centre Jülich, Germany d Department of Electronic Engineering, Tohoku University, Japan |
| Abstract: | A new LAPS (light-addressable potentiometric sensor) set-up will be introduced, in which the light sources are miniaturised by the utilisation of a VCSEL (vertical-cavity surface-emitting laser) array to increase the measurement spot density. An FPGA (field-programmable gate array) is used to generate modulation signals for individual illumination of each measurement spot of the LAPS. The new set-up can operate a large number of measurement spots simultaneously by reading out the sum photocurrent and separate the signals of the individual measurement spots by an FFT analysis. The frequency, amplitude and offset of the modulation signal can be configured for each measurement spot by software. The new system can be combined with a positioning stage allowing the parallel read out of a single line of measurement spots and a scan perpendicular to that line in a similar manner, like for an optical scanner set-up. First measurements demonstrate the functionality of the new LAPS set-up as a chemical imaging system. |
| Keywords: | Light-addressable potentiometric sensor Biosensor Chemical imaging FPGA LAPS Field effect |
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