1种基于信息理论的新分子序列度量法

传统的方法度量序列之间的距离需要序列比对,使一些主观因素破坏数据的原始状态,导致计算结果因人而异。本文拟介绍一些基于信息理论的度量法,提出1种类似的新度量法,建立数学依据。这些度量法度量序列之间的距离不需要序列比对,没有主观因素干涉。同时,选取了20种胎生哺乳动物的线粒体全基因序列,分别使用这些度量法计算出他们的距离,再利用NEIGHBOR法构建系统树。由比较结果看来,新方法用较少时间构建的系统树完全不逊色于以往的方法。这为研究分子序列的差异性提供了1种新方法。

A new measure based on shannon information for biologic sequence

Traditional sequence distances require an alignment and therefore are not directly applicable to the moreproblem of whole genome phylogeny where events such as rearrangements make full length alignments impossible.This paper introduces information theoretical concept and arithmetic which is used to compute information probability distribution of sequence.Some information theory-based measures are also introduced,which are used to measure discrepancy of information probability distribution,such as Kullback-L...