Molecular and immunologic aspects of the nonclassical HLA class I antigen HLA-G: evidence for an important role in the maternal tolerance of the fetal allograft

To support collaborative engineering, it is important not only to share information, but also to manage that information in a manner that actively promotes integration. This paper describes the central models underlying the COMMIT (construction modeling and methodologies for intelligent integration of information) project, which is defining mechanisms to handle a number of issues relating to the management of information to support decision-making in collaborative projects. Examples are given to illustrate the implementation of the COMMIT information management concepts. The project is being carried out in consultation with a well-established steering group comprising standardization bodies, industries, and researchers. The COMMIT project is supported by the Engineering and Physical Sciences Research Council, United Kingdom.