阻断HIV-1进入细胞的抑制剂研究

为了解决HlV-1病毒耐药的难题，研究阻断病毒进入细胞的抑制剂是一个重要途径，通过对近年来国 内外学者在阻断HIV-1病毒进入宿主细胞的抑制剂方面所发表的文献进行分析，概述了阻断HIV-1病毒进入宿主细胞的抑制剂的研究进展．阻断病毒进入细胞的抑制剂具有强大的抗逆转录病毒作用，它的优势在于可以对抗目前所有的HIV-1耐药毒株，它分为阻断病毒与细胞吸附的抑制剂、阻断病毒进入的抑制剂及阻断病毒与细胞融合的抑制剂．提出了研究抑制剂时可考虑的几个不同靶点．

Study on Inhibitors Preventing HIV-1 Virus From Entering Host Cell

order to solve the difficult problem of HTV-1 viral resistence to drugs, the research on the inhibitor preventing virus from entering host cell is very important countermeasure. The present situation and developing trend of this kind inhibitors are summarized and the newest international research fruits are presented. Not only might such entry inhibitors increase the potency of initial HIV treatment, but they may also provide hope for patients who have exhausted current treatment options. Since there are several possible targets, there is also possibility to develop the drugs with synergistic effects in inhibiting viral entry. Three major steps in viral entry have been targeted for drug design: inhibition of CD4 binding, inhibition of coreceptor binding, and blocking of the gp41 conformational changes that permit of viral fusion. Daring studying the anti-HTV inhibitor, several targets are considered.