A computer-controlled spraying-freezing apparatus for millisecond time-resolution electron cryomicroscopy |
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Authors: | HD White ML Walker J Trinick |
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Affiliation: | Gladstone Institute of Cardiovascular Disease and Department of Medicine, University of California, San Francisco 94141-9100, USA. |
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Abstract: | The application of gene therapy techniques to the clinical problem of coronary restenosis has generated tremendous attention and enthusiasm. Use of gene transfer technology to prevent a common intractable illness would represent a watershed event for human gene therapy. However, the time is not yet right to initiate gene therapy trials for restenosis. The biology of restenosis is incompletely understood, catheter-based gene delivery is poorly adapted to the coronary circulation, and current gene transfer vectors are ill-suited for safe and effective gene delivery to the coronary artery wall. Basic research designed to overcome these obstacles is currently more appropriate than the initiation of clinical trials. |
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