| 鞣花酸衍生物的合成及抑制HCV NS3蛋白酶活性 |
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| 引用本文： | 王悦,李正全,徐筱杰.鞣花酸衍生物的合成及抑制HCV NS3蛋白酶活性[J].佳木斯工学院学报,2011(6):884-886,895. |
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| 作者姓名： | 王悦 李正全 徐筱杰 |
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| 作者单位： | [1]中国人民解放军防化学院化生防护系,北京102205 [2]中国广州分析测试中心,广东广州510070 [3]北京大学化学与分子工程学院,北京100871 |
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| 基金项目： | 国家自然科学基金资助项目（71041024） |
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| 摘 要： | 从中草药叶下珠中活性追踪、提取出具有体外抑制HCV NS3丝氨酸蛋白酶活性的先导化合物——鞣花酸,进而化学合成鞣花酸的衍生物并用NMR和MS确定结构;采用ELISA法测定了所合成鞣花酸衍生物体外抑制HCV-NS3丝氨酸蛋白酶的活性.
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| 关 键 词： | 鞣花酸衍生物 合成 ELISA HCV NS3丝氨酸蛋白酶 |
Synthesis of Derivatives of Ellagic Acid and Their Inhibitory Activities on HCV NS3 Protease |
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| Authors: | WANG Yue LI Zheng-quan XU Xiao-jie |
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| Affiliation: | 1.Chemical Defence Institute of The PLA,Beijing 102205,China;2.China National Analytical Center,Guangzhou 510070,China;3.College of Chemistry and Molecular Engineering,Peking University,Beijing 100871,China) |
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| Abstract: | Under the guidance of bioassay,ellagic acid was extracted from plant Phyllanthus urinaria L.as precursor of inhibitors of HCV NS3 serine protease.its derivatives were chemically synthesized and their structures were elucidated by NMR and MS.The inhibitory activities of the derivatives of ellagic acid on HCV NS3 serine protease invitro were tested through ELISA. |
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| Keywords: | Derivative of ellagic acid synthesis ELISA HCV NS3 serine protease |
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