Microparticles of novel branched copolymers of lactic acid and amino acids: preparation and characterization |
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Authors: | G Caponetti JS Hrkach B Kriwet M Poh N Lotan P Colombo R Langer |
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Affiliation: | National Institutes of Health, Warren Grant Magnuson Clinical Center, Building 10, Rm 7D-43, 10 Center Drive, MSC-1662, Bethesda, MD 20892- 1662, USA. nogrady@cc.nih.gov |
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Abstract: | Macrophage inflammatory protein (MIP)-1alpha and MIP-1beta regulate leukocyte activation and trafficking. To assess the role of MIP-1alpha and MIP-1beta in human inflammation, healthy subjects were studied during experimental endotoxemia with prior administration of ibuprofen, a cyclooxygenase inhibitor, or dimeric p75 tumor necrosis factor (TNF)-alpha receptor, a TNF antagonist; septic patients were also studied. Following endotoxin, blood levels of both MIP-1 molecules rose acutely and fell to baseline by 6 h (P=. 001). While MIP-1 mediates fever in animals independent of cyclooxygenase blockade, in subjects given endotoxin and ibuprofen, MIP-1 levels increased and fever was suppressed. MIP-1 levels were not diminished by inhibiting circulating TNF-alpha in humans. In septic patients, elevated levels of MIP-1alpha and MIP-1beta were detected within 24 h of sepsis and fell in parallel with TNF-alpha and interleukin-6 (P<.01). MIP-1alpha and MIP-1beta increase during acute inflammation but are not associated with fever in endotoxemic humans during cyclooxygenase blockade. |
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