食品中有害物苯并[a]芘诱导结肠毒性的研究进展

苯并a]芘是多环芳烃类物质,广泛存在于高温加工食品中,且工业生产和生活中燃料不完全燃烧也会产生大量苯并a]芘,进而通过水源、空气和土壤等污染食物.流行病学调查显示,苯并a]芘与结肠癌、结肠炎症等肠道疾病的发生密切相关.作者详细综述了不同食品中苯并a]芘的含量,及其诱发结肠癌、结肠氧化损伤、结肠炎症、肠道菌群失调...

Research Progress on Colonic Toxicity Induced by Foodborne Benzo[a]pyrene

Benzoa]pyrene is a kind of polycyclic aromatic hydrocarbon and widely found in high- temperature processed food. Moreover, incomplete combustion of fuel in industrial production and daily life also produce a huge number of benzoa]pyrene, which further contaminates food through water, air and soil source. Epidemiological investigation shows that benzoa]pyrene is closely related to colon cancer, colon inflammation and other intestinal diseases. Therefore, this paper summarized in detail the content of benzoa]pyrene in different foods and the related molecular mechanisms of colonic toxicity that induce colon cancer, colon oxidative damage, colon inflammation and intestinal flora imbalance, aiming to fully reveal the colonic toxicity of foodborne benzoa]pyrene and to provide a reference for its toxicity control and protection of human health.