| 一种简易合成3,5-二氨基吡啶的方法 |
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| 引用本文： | 梁长玉,胡炳成,戴红升,孙呈郭,徐士超.一种简易合成3,5-二氨基吡啶的方法[J].含能材料,2011,19(5):513-517. |
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| 作者姓名： | 梁长玉 胡炳成 戴红升 孙呈郭 徐士超 |
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| 作者单位： | 南京理工大学化工学院,江苏南京,210094 |
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| 基金项目： | 国家部委基金资助(No. HZY09020302-7) |
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| 摘 要： | 研究了一种简易合成3,5-二氨基吡啶及其氨基被保护的衍生物的方法,以3,5-二甲基吡啶为原料,经高锰酸钾氧化、酰胺化和霍夫曼降解简便的三步反应合成了3,5-二氨基吡啶及3,5-二甲氧羰基氨基吡啶,总收率分别在70％和72％以上.讨论了各步反应主要的影响因素,并用1H NMR、MS/MS、IR、元素分析等方法对中间体和产...
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| 关 键 词： | 有机化学 3 5-二甲基吡啶 3 5-二氨基吡啶 霍夫曼降解 3 5-二甲氧羰基氨基吡啶 |
| 收稿时间： | 2010/11/8 0:00:00 |
| 修稿时间： | 4/21/2011 3:52:04 PM |
A Simple Method for Preparing 3,5-Diaminopyridine |
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| LIANG Chang-yu,HU Bing-cheng,DAI Hong-sheng,SUN Cheng-guo and XU Shi-chao.A Simple Method for Preparing 3,5-Diaminopyridine[J].Chinese Journal of Energetic Materials,2011,19(5):513-517. |
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| Authors: | LIANG Chang-yu HU Bing-cheng DAI Hong-sheng SUN Cheng-guo and XU Shi-chao |
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| Affiliation: | LIANG Chang-yu,HU Bing-cheng,DAI Hong-sheng,SUN Cheng-guo,XU Shi-chao(School of Chemical Engineering,Nanjing University of Science & Technology,Nanjing 210094,China) |
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| Abstract: | 3,5-Diaminopyridine(DAP) and 3,5-dimethoxycarbonylaminopyridine(DMAP) were synthesized from 3,5-dimethylpyridine via a three-step reaction(oxidation,ammoniation and Hofmann degradation) with the yields of 70%(for DAP) and 72%(for DMAP).This procedure possesses advantages of mild conditions,easy operation,high yield and environmentally-friendly.A number of influencing factors for each step were investigated and discussed.The intermediates and target compounds structures were characterized by 1H NMR,MS/MS,IR ... |
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| Keywords: | organic chemistry 3 5-dimethylpyridine 3 5-diaminopyridine Hofmann degradation 3 5-dimethoxycarbonylaminopyridine |
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