| 3-溴-1-(3-氯-2-吡啶基)-4,5-二氢-1H-吡唑-5-甲酸乙酯的合成研究 |
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| 引用本文： | 吴永果,毛春晖,兰支利.3-溴-1-(3-氯-2-吡啶基)-4,5-二氢-1H-吡唑-5-甲酸乙酯的合成研究[J].精细化工中间体,2007,37(5):15-17. |
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| 作者姓名： | 吴永果 毛春晖 兰支利 |
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| 作者单位： | 1. 湖南师范大学,化学化工学院,湖南,长沙,410081
2. 湖南化工研究院,国家农药创制工程技术研究中心,湖南,长沙,410007 |
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| 摘 要： | 3-溴-1-(3-氯-2-吡啶基)-4,5-二氢-1H-吡唑-5-甲酸乙酯是合成新型鱼尼丁受体杀虫剂氯虫酰胺(chlorantraniliprole)的关键中间体。笔者以2-(3-氯-2-吡啶基)-5-氧-3-吡唑烷甲酸乙酯为原料,经对甲苯磺酰氯酯化、再溴化两步合成,总收率91.0%,产品含量98.0%,合成工艺简单,成本较低,并有望工业化。
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| 关 键 词： | 2-(3-氯-2-吡啶基)-5-氧-3-吡唑烷甲酸乙酯 3-溴-1-(3-氯-2-吡啶基)-4 5-二氢-1H-吡唑-5-甲酸乙酯 氯虫酰胺 合成 |
| 文章编号： | 1009-9212（2007）05-0015-03 |
| 修稿时间： | 2007-07-20 |
Synthesis of Ethyl 3-Bromo-1-(3-chloro-2-pyridinyl)-4,5-dihydro-1H-pyrazole-5-carboxylate |
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| WU Yong-guo,MAO Chun-hui,LAN Zhi-li.Synthesis of Ethyl 3-Bromo-1-(3-chloro-2-pyridinyl)-4,5-dihydro-1H-pyrazole-5-carboxylate[J].Fine Chemical Intermediates,2007,37(5):15-17. |
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| Authors: | WU Yong-guo MAO Chun-hui LAN Zhi-li |
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| Affiliation: | 1. College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081, China; 2. National Engineering Research Center for Agrochemicals, Hunan Research Institute of Chemical Industry, Changsha 410007, China |
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| Abstract: | Ethyl 3-bromo-1-(3-chloro-2-pyridinyl)-4,5-dihydro-1H-pyrazole-5-carboxylate is an important intermediate of a new insecticide chlorantraniliprole. It was synthesized from ethyl 2-(3-chloro-2-pyridinyl)-5-oxo-3-pyrazolidinecarboxylate through esterification and bromination. The total yield and purity of the product was 91.0% and 99% respectively,indicating that this was a promising industrialization route because of its simply synthetic process and low cost |
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| Keywords: | 2-(3-chloro-2-pyridinyl)-5-oxo-3-pyrazolidinecarboxylate 3-bromo-1-(3-chloro-2-pyridinyl)-4 5-dihydro-1H-pyrazole-5-carboxylate chlorantraniliprole synthesis |
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