Linkage of proximal myotonic myopathy to chromosome 3q |
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| Authors: | K Ricker T Grimm MC Koch C Schneider W Kress CD Reimers W Schulte-Mattler B Mueller-Myhsok KV Toyka CR Mueller |
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| Affiliation: | Department of Neurology, University of Würzburg, Germany. Kenneth.Ricker@t-online.de |
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| Abstract: | We performed genetic linkage analysis in nine German proximal myotonic myopathy (PROMM) families using DNA-markers D3S1541 and D3S1589 from the region of the recently discovered gene locus of myotonic dystrophy type 2 (DM2) on chromosome 3q. Two-point analysis supplied an lod score of 5.9. We conclude that a gene causing PROMM is located on chromosome 3q. PROMM and DM2 may be allelic disorders or may be caused by closely linked genes. |
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