| CaO-P2O5-SiO2系统溶胶-凝胶玻璃的生物矿化行为 |
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| 引用本文： | 陈晓峰,王迎军,赵娜如,郑裕东. CaO-P2O5-SiO2系统溶胶-凝胶玻璃的生物矿化行为[J]. 材料研究学报, 2003, 17(3): 268-275 |
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| 作者姓名： | 陈晓峰 王迎军 赵娜如 郑裕东 |
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| 作者单位： | 华南理工大学材料学院生物材料研究所 |
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| 基金项目： | 国家自然科学基金，国家高技术研究发展计划(863计划)，59932050、59872010，2001AA320607，， |
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| 摘 要： | 利用体外实验方法(in vitro)以及XBD、SEM、FTIR、BET、ICP等手段研究了两种溶胶一凝胶生物活性玻璃的显微结构及其在模拟生理溶液(SBF)中的降解过程、表面反应产物和生物矿化机理．结果表明，两种生物活性玻璃都具有较高的生物活性，均具有由纳米尺寸颗粒相互连接而成的微孔结构和较大的比表面积，在模拟生理溶液(SBF)中浸泡后可形成表面类似天然骨中无机矿物的碳酸经基磷灰石层(HCA)，说明两者均具有较高的生物活性和生理环境相应特性．材料表面的硅酸凝胶层及其硅经基团的形成对碳酸经基磷灰石(HCA)微晶的成核有重要作用。
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| 关 键 词： | 无机非金属材料 生物活性材料 模拟生理溶液 可降解性 生物矿化 |
| 文章编号： | 1005-3093(2003)03-0268-08 |
| 修稿时间： | 2002-06-28 |
BIO-mineralization behavior of the sol-gel derived glasses in the system CaO-P2O5-SiO2 in a biological environment |
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| CHEN Xiaofeng WANG Yingjun ZHAO Naru ZHENG Yudong. BIO-mineralization behavior of the sol-gel derived glasses in the system CaO-P2O5-SiO2 in a biological environment[J]. Chinese Journal of Materials Research, 2003, 17(3): 268-275 |
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| Authors: | CHEN Xiaofeng WANG Yingjun ZHAO Naru ZHENG Yudong |
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| Abstract: | The microstructure, degradability, surface reaction products and mechanism of mineralization in SBF solution of the two sol-gel derived glasses in the system CaO-P2O5-SiO2 were investigated in vitro using XRD, SEM, FTIR, BET and ICP techniques. The results show that both sol-gel glasses have high bioactivity owing to rapid formation of hydroxy-carbonate-apatite (HCA) on the biomaterials'surface in SBF and the different behaviors of ion diffusion and bio-mineralization in SBF solution due to their different composition. The silicic acid gelatin and the formation of Si hydroxy group on the materials' surface had an important effect on nucleation and amount of HCA. |
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| Keywords: | inorganic non-metallic materials bioactive materials simulated body fluid (SBF) degradation bio-mineralization |
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