Inhibition of xanthine oxidase activity by an oxathiolanone derivative of quercetin |
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| Authors: | Umeo Takahama Yukiko Koga Sachiko Hirota Ryo Yamauchi |
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| Affiliation: | 1. Department of Bioscience, Kyushu Dental College, Kitakyushu 803-8580, Japan;2. Department of Applied Pharmacology, Kyushu Dental College, Kitakyushu 803-8580, Japan;3. Department of Nutritional Science, Kyushu Women’s University, Kitakyushu 807-8586, Japan;4. Department of Applied Life Science, Faculty of Applied Biological Sciences, Gifu University, Gifu 501-1193, Japan |
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| Abstract: | An oxathiolanone derivative of rutin could be produced in the stomach after the ingestion of rutin containing foods, and the oxathiolanone derivative could be hydrolysed to an oxathiolanone derivative of quercetin (quercetin-oxathiolanone) in the intestine. Quercetin-oxathiolanone as well as quercetin inhibited xanthine oxidase. Approximately 0.05 μM quercetin-oxathiolanone inhibited the activity by 50%, whereas 50% inhibition by quercetin was observed at approximately 0.4 μM. The results suggested that quercetin-oxathiolanone can be used as an effective inhibitor of xanthine oxidase and that the ingestion of rutin-rich foods may be useful to prevent the increase in the blood concentration of uric acid. |
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| Keywords: | Oxathiolanone derivatives Quercetin Rutin Xanthine oxidase |
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