Shelf life and delivery enhancement of vitamin C using chitosan nanoparticles |
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| Authors: | A. Alishahi A. Mirvaghefi M.R. Tehrani H. Farahmand S.A. Shojaosadati F.A. Dorkoosh Maher Z. Elsabee |
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| Affiliation: | 1. Department of Fisheries and Environmental Sciences, Tehran University, Karaj, Iran;2. Department of Pharmaceutics, Tehran University of Medical Sciences, Tehran, Iran;3. Department of Chemistry and Engineering, The University of Tarbirt Modares, Tehran, Iran;4. Department of Chemistry, Faculty of Science, Cairo University, Cairo 12613, Egypt |
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| Abstract: | Chitosan with different molecular masses was reacted with sodium tripolyphosphate (STPP) to prepare different size nanoparticles, in which vitamin C was encapsulated. The effect of molecular weight (Mw) on nanoparticles efficiency, nanoparticles yield, size, and zeta potential was investigated in detail. Low Mw chitosan generated nanoparticles with better size, morphology, and delivery rate. In addition, the shelf life of encapsulated vitamin C increased as compared with its non-encapsulated counterpart. The release of vitamin C from the nanoparticles was pH-dependent. Quick release took place in 0.1 M phosphate buffer solution (PBS, pH 7.4), while the release was slow in 0.1 M HCl. In addition, in vivo release rate in digestive tract of rainbow trout nearly showed the same trend as the in vitro one. |
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| Keywords: | Chitosan nanoparticles Vitamin C encapsulation Shelf life Controlled release |
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